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Description

Similarly, the reduction in EGR1 and FOS suggests a potential mechanism for curbing death receptor signaling and activator protein-1 (AP-1)-mediated inflammation 67,68,69 , While the downregulation of MAP3K8 (TPL2) might modulate the balance between the TGF- -Activated Kinase 1 (TAK1)-NFB and ASK1-c-Jun N-terminal Kinase (JNK) pathways 70

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The peptide is engineered with a fatty-acid moiety to extend its circulation time (half-life ~6 days), allowing for once-weekly dosing [2]

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87 , Alnahdi et al

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