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However, due to the increased risk of adverse gastrointestinal (GI) and cardiovascular (CV) events, dosing in geriatric patients should be done with caution because of age-related decreases in renal function and concomitant disease and drug therapy

This absence of IGF-1 stimulation is critical for appetite neutrality because IGF-1 has known effects on hypothalamic neuropeptide expression, including alterations to neuropeptide Y (NPY) and agouti-related peptide (AgRP), both potent appetite stimulators

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A Cochrane Review of vitamin and mineral supplements to maintain cognitive function in cognitively healthy people included 14 studies that compared folic acid, vitamin B12, vitamin B6, or a combination of these supplements to placebo in 27,882 participants, most of whom were age 60 years or older [97]