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Resveratrol, a promising pigment-lightening flavonoid found in red wine, was recently found to suppress TYR expression not via the inhibition of MITF expression, but by directly inhibiting TYR activity by a post-translational modification that reduces the levels of fully mature TYR protein (119)

Brain aging increases sensitivity to OS and decreases the effectiveness of antioxidant defenses, causing functional deficiencies, inflammation, decreased elasticity and greater susceptibility to the etiological factors involved in the pathogenesis of neurodegenerative disease (Federico et al., 2012

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