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In a skincare product context this reaction is a formulation stability problem, not necessarily a skin toxicity catastrophe, but it destroys the functional complex and can cause the product to oxidize and discolor

Disruptions in the gut, such as gastrointestinal disorders, diseases affecting the ileum, or conditions that affect the production of intrinsic factor, can lead to poor vitamin B12 absorption

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Furthermore, western blot results revealed a significant decrease in the protein levels of N-cadherin and Vimentin, whereas the expression level of E-cadherin was markedly increased (Fig