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GPER may also modulate the thyroid-stimulating hormone (TSH) signaling pathway, directly impacting the effects of TSH on thyroid function and influencing thyroid hormone synthesis and secretion [207,208,209]

To test for a link between insulin and mTOR-dependent effects on FGF21, HepG2 cells were treated with an insulin concentration similar to the one detected in serum of mice after 3 h MR (e.g., 2 nM)

It is commonly believed that hypothyroidism is a chronic condition without a definitive cure, necessitating a lifetime of management through thyroid medication such as levothyroxine