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42 Conversely, in a prospective casecontrol study encompassing 600 pregnant women diagnosed with RLS/WED, the investigators discovered that a reduction in iron intake and an elevation in magnesium consumption were correlated with an exacerbation of the syndromes symptoms

There are studies indicating that ozone therapy stimulates glutathione production

Catechol-O-methyltransferase inhibition with entacapone: evidence from controlled clinical trials in Parkinsons disease

Citing these recent works will both address the reviewers concern about currency and strengthen the argument that GSH-responsive strategies are maturing toward precision, clinically relevant theranostics [20]