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In addition, folate is synthesized and stored as poly-gamma-glutamate forms in plant cells and can be hydrolyzed into mono-glutamic forms by the enzyme gamma-glutamyl hydrolase (GGH), which has an important influence on the cellular homeostasis of folate [1, 24, 28]

Early intervention efforts for prodromal symptoms are being explored in patients with schizophrenia, including the incorporation of ITC like SF in the diet (44)

3.5 IDO IDO1 is a well-established immunosuppressive enzyme, depleting tryptophan and generating kynurenine to inhibit effector T cells

The gut microbiota metabolite capsiate regulate SLC2A1 expression by targeting HIF-1alpha to inhibit knee osteoarthritis-induced ferroptosis