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10.1155/2020/8886715 49 ZhaoJ.JungY

In the Down syndrome population, therapies targeting IDO1 or its upstream pathways (i.e., Janus-activated kinase [JAK]), were proposed to ameliorate some of the accompanying comorbidities (41)

note that MMA is not universally available on the NHS and can also be raised in renal impairment Homocysteine raised in both B12 and folate deficiency