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The adverse and beneficial effects of polyphenols in green and black teas in vitro and in vivo

(2020) reported that JNK negatively regulates nuclear receptor coactivator 4 expression to inhibit ferroptosis

In HK-2 proximal tubular cells, hyperglycemia suppressed NRF2 and downstream expression of a newly identified target gene encoding mitochondrial ribosomal protein ( MRPL12 ), resulting in defective oxidative phosphorylation and increased production of ROS (123)