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During aging, chaperones may act as suicide proteins, neutralizing toxic effects of abnormal proteins by binding to them and thereby sacrificing their own activity to protect other cellular proteins 61,95

Our group previously demonstrated that an RNA-binding protein, HuR, translocates to the cytoplasm under acute metabolic stress to support these and other survival pathways ( 17 )

Acute respiratory distress syndrome (ARDS) involves neutrophil accumulation in alveolar spaces and NSP release, causing alveolar-capillary barrier damage and exacerbated inflammatory responses ( Autoimmune diseases present additional possibilities