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& Goeddel, D

The final assessment of these serious adverse events described them as akathisia secondary to venlafaxine treatment and not serotonin syndrome.55 The second case was a patient who was hospitalized for drug overdose while receiving STS in an open-label extension study following double-blind therapy.55 The patient had been taking several contraindicated medications, including nortriptyline, bupropion, and a sympathomimetic agent for weight loss, and was wearing 2 STS patches simultaneously (12 mg/24 hours each)

Food and Drug Administration (FDA)

Ibiye Owei, Assistant Professor at Texas Tech University Health Sciences Center El Paso, explained that metabolic adaptation occurs while patients are losing weight on Ozempic and this can contribute to weight gain when the medication is ended