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In the phase 3 ELOQUENT-2 clinical trial in patients who had previously received one to three prior lines of therapy, PFS between groups favored elotuzumab with lenalidomide and dexamethasone versus lenalidomide and dexamethasone at 1 year (68% vs 57%) and 2 years (41% vs 27%)

In the meantime, vitamin B12-fortified foods and supplements remain the most reliable source of vitamin B12 for vegetarians and vegans

the standard BNF loading regimen is 1 mg on alternate days for two weeks, followed by 1 mg every three months for maintenance

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