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Curcumin induced CYP3A4 in multiple models, including HepG2 cells ( Curcumin may reduce CYP19A1 expression levels by suppressing ERR, a mechanism independent of ATZ As previously mentioned, CYP19A1 plays a critical role in the last step of estradiol biosynthesis

However, its effects on cardiovascular health, particularly in diabetic and pre-diabetic populations, have been less clear

Additionally, activation of NF-E2-related factor 2 (NRF2) transcriptionally elevates FTH1 and FTL expression, while NRF2 knockout sharply decreases their expression [48]

Male Wistar rats were divided into five groups: one control (untreated) and four NiCl 2 -treated groups, each receiving single oral dose of NiCl 2 at 45, 90, 135, and 180 mg/kg body weight