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This addition of arginine appears to give the molecule privileged access to nerve cells, priming them for the effects of nerve growth factor and other factors important in the development and function of nerve cells.58,59 Acetyl-L-carnitine alone is known to be neuroprotective, reducing the rate of nerve cell death in cultured cells exposed to some of the neurotoxic agents that are important in the development of Alzheimers disease.16 The observation that acetyl-L-carnitine makes cultured nerve cells much more sensitive to the effects of nerve growth factor,60,61 thereby rescuing them from the effects of aging, led scientists to seek out other compounds with this remarkable capability

doi: 10.1530/EC-190382 49 FeldmanELCallaghanBCPop-BusuiRZochodneDWWrightDEBennettDLet al

Supplementary material The Supplementary Material for this article can be found online at: References 1 AgnaniD.Camacho-VanegasO.CamachoC.LeleS.OdunsiK.CohenS.et al (2011)