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Using an in vitro PHGDH enzyme assay, they determined CBR-5884 to be a weak and selective PHGDH inhibitor (IC 50 = 33 12 mM), whose mode of action involves the disruption of the enzymes tetrameric state in favour of the dimeric conformation 20

Variability between genetically distinct populations Certain cell surface proteins exhibit a genetically determined high degree of inter-donor variability in expression, including CR1 and complement molecules C4A and C4B 31,32

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The inclusion and exclusion criteria were defined in direct accordance with the PICOS framework