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It works through a different mechanism (fat oxidation via beta-3 adrenergic receptors, not appetite suppression), and that mechanism produces gradual, subtle changes

The Lee 2016 trial measured outcomes at 6 months that timeline is grounded in the biology of hair [4]

While the flow cytometric apoptosis reduction (3.48%) was not statistically significant, the molecular markers (caspase-3 down 42.7%, PARP down 77.5%, Bcl-2/Bax shift) were all highly significant

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