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Adaptation condition and selection of adapted strains Adaptive experiments were performed using wild-type strain W78 and mutant strain M1 on CM17 solid medium containing gradually increasing concentrations of acetoacetanilide as a stressor (800 to 2000 mg/L, in 100 mg/L incremental steps)

2) and amino acids from 9.4 to 12 and finally to 15.1 months, together with the statistical data (Tables 1 and 2) were used derive interpretations of metabolic pathways

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