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Safety, tolerability, and efficacy results trial of AVP-923 in PBA investigators

(2020) 180:10811097.e24

Adverse Reactions / Side Effects In most cases, methylcobalamin is nontoxic, even in large doses

Shungu Once the process starts, it can be hard to tell what is causing what as the mitochondrial and oxidative stress problems feed into each other: In our study of primary mitochondrial disorders (e.g., MELAS), we have found a cortical GSH deficit that seems to be even bigger than in ME/CFS, meaning that mitochondrial dysfunction and oxidative stress co-exist and likely potentiate and sustain each other in such disorders