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SKU: 34761267009
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Neurochemistry International, 63 (8), 726731

However, the mechanism by which truncated Syn variants sequester cellular proteins and damaged organelles to drive LB nucleation remains poorly understood

doi:10.1002/jcsm.12611 [PubMed] 124

Disruption of this regulatory circuit, as observed in PD patients with lower heart rate variability (a sign of vagal dysfunction), causes exacerbated systemic inflammation and greater microglial priming once peripheral cytokines or endotoxins reach the CNS [121]