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[9,10,22,24,25,27,28,42, 43, 44, 45, 46] The target immune cells in this strategy are autoreactive T cells, regulatory T cells (T regs ), and tolerogenic dendritic cells (tol DCs), as schematized in Figure 1 for SLE

This is followed by endonuclease digestion using Sfil and Notl enzymes and ligation to Sfil and Notl cleaved pCantab5E (Pharmacia)

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