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Description

Subsequent phosphorylation of C-terminal tyrosines (Y1349 & Y1356) creates a multifunctional docking site that recruits signal transducing proteins including GAB1 and GRB2

10.4155/fmc-2016-0189 125

Peptide pools more reliably broaden the cytotoxic T-cell repertoire and may improve outcomes within individual cohorts, but a clear survival advantage over single-peptide strategies has not been demonstrated in randomized melanoma trials (Table 1)