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Graphical Abstract Doxorubicin (DOX)-induced chemobrain may occur because of increased tumor necrosis factor-alpha (TNF-) levels in the brain, which activates inhibitory-kappa B kinase (IKK), thus triggering the dissociation of nuclear factor kappa B (NF-B) from its inhibitor protein

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Short SP, Barrett CW, Stengel KR, Revetta FL, Choksi YA, Coburn LA , Lintel MK, McDonough EM, Washington MK, Wilson KT, Prokhortchouk E, Chen X, Hiebert SW, Reynolds AB, Williams CS