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214 To investigate the effect of reducing lncExACT1 in physiological cardiac hypertrophy and in the protection against cardiac remodeling, a tail vein injection of the LNA antisense oligonucleotide (GapmeR) specific to lncExACT1 led to reduced lncExACT1 expression which induced physiological cardiac hypertrophy and protected against cardiac remodeling and heart failure

Under physiological conditions, the cytoplasmic protein Kelch-like ECH-associated protein 1 (Keap1), an adapter protein of Cullin-3-based ubiquitin ligase, binds to NRF2 to suppress NRF2 activation by mediating its ubiquitination and degradation (Fig

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Key Takeaways Epithalon is a synthetic tetrapeptide that supports longevity, deep sleep, and cellular renewal through a mechanism linked to the pineal gland and telomere biology