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E., van Burik, J

In addition, mTORC1 activity in eIF2 KD cells was examined by detecting the phosphorylation of its substrates 4EBP1 (Ser65), S6K (Thr389), ULK1 (Ser757) and TFEB (Ser142), revealing that mTORC1 inactivation was not affected by eIF2 depletion upon lysosomal damage (Fig

the diagnosis and management portions of the algorithm (see Figure 1), therefore, are provided as Clinical Principles or as Expert Opinion with consensus achieved using a modified Delphi technique if differences of opinion emerged