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Perceived primary care safety was low

restarting acetaminophen [~1 g/day for 2 days] was followed by acute rise in ALT to 3216 U/L but normal bilirubin, resolving rapidly

In a rat model, melatonin demonstrated inhibition of NMDA receptor activation and subsequent NMDA receptor-mediated Ca 2+ entry into striatal neurons, suggesting a potential protective role [79]