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Additionally, in BV2 microglia exposed to isoflurane, MTZ decreased the expression of the protein Iba1 and decreased the production of the proinflammatory mediators interleukin (IL)-1 and IL-18, which isoflurane produces by blocking the activation of the nod-like receptor family protein 3 (NLRP3) inflammasome in BV2 microglia

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Specifically, we applied stereotactic administrations of 0.1% LPC into the corpus callosum and sorted O4 + OLs during the remyelination phase

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