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IGF-1 LR3 (Insulin-like Growth Factor-1 Long R3) is a recombinant analog of human IGF-1 with an 83-amino-acid sequence and an N-terminal extension that extends its half-life to approximately 2030 hours compared to endogenous IGF-1's 10-minute half-life

Within endosomes, zinc contributes to tethering and fusion by stabilizing zinc-dependent tethering factors, such as the zinc finger protein EEA1, which facilitates SNARE complex assembly and ensures efficient cargo sorting and receptor recycling 99,100

Peterson SM, Pack TF, Wilkins AD et al (2015) Elucidation of G-protein and -arrestin functional selectivity at the dopamine D2 receptor

Importantly, there was no significant difference in apoptosis between the OE-SCARA5 + agmir-425-5p group and the Control group, nor between the Control+agmir-425-5p group and the sh-SCARA5 group (Fig