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In addition, blood transfusions necessary in the treatment of some diseases may also increase the iron content in the body

The relationships between these changes and different rates of decline of fasting C-peptide/glucose suggest both a basis for the stratification of individuals with type 1 diabetes and a window for intervention

Overall, the review highlights metabolism as a key determinant of GBM pathophysiology and a promising target for therapeutic innovation, emphasizing the importance of continued translational research to identify and exploit context-specific metabolic vulnerabilities in this highly lethal disease