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A controlled Phase III trial of dichloroacetate in children with pyruvate dehydrogenase complex deficiency (ClinicalTrials.gov ID#: NCT02616484), using a validated parental observation of child behavior scale as the primary outcome measure is undergoing result analysis and FDA review

The discovery of parkin and UCH-L1 mutations, as well as their involvement in the ubiquitin-proteasomal system, ushered in a new age of research into changes in protein processing in dopaminergic cells via both proteasomes and lysosomes (Eldeeb et al., 2022

Synergistically interacting dopamine D1 and NMDA receptors mediate nonvesicular transporter-dependent GABA release from rat striatal medium spiny neurons

Nutrition plays a crucial role in shaping the reproductive outcomes of ruminants (Robinson et al., 2006)