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In preclinical models, treatment with a dual arginase inhibitor OATD-02 led to an immunostimulatory state via increased intratumoral L-arginine, increased immune cell infiltration, and improved response to immune checkpoint blockade ( In a human study examining the metabolic phenotype of lymph node aspirates in patients with NSCLC versus non-malignant conditions, no single metabolomic feature was able to differentiate malignant status or histologic type, but differences were seen in metabolites including kynurenine and oxidized glutathione (72)

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Long D, Mao C, Huang Y, Xu Y, Zhu Y

(Landmark Ed.) 28 , 203 (2023)