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After 48 h, the cells were treated with PBS (in Con group) and 100 M Hcy (in Hcy group) for 24 h

Another new insight came from knock-out of the mysterious type 2 IGF receptor, identical to the mannose-6 phosphate receptor (M6P-R), specifically binding IGF-II and involved in internalization of proteins for lysosomal degradation

The results were in favor of the combined therapy while the greater dosage resulted in greater weight loss with mean weight loss -7.8kg, -9.8kg, and -1.2kg in the three respective groups (85)

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