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These issues have pushed researchers to explore genetically engineered models by targeting genes integral to the uptake or metabolism of VitB12, thereby aiming to establish systems that recapitulate VitB12 deficiency (see below)

27, 28, 29 In cancer, aberrant DNA methylation is typically observed in the promoter regions of various tumor suppressor genes and microRNAs, 30, 31, 32, 33, 34, 35, 36, 37, 38 leading to their transcriptional silence