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In eukaryotes, the activation of signaling cascades uses a different strategy

Numerous reports have demonstrated the beneficial impact of ART (Antiretroviral Therapy) on innate immune cells, leading to the restoration of normal immune cell frequencies and markers after therapy (261, 267)

Hydroxyl radical (OH) directly generated from the Fenton reaction abstracts a hydrogen from PUFAs, forming a phospholipid carbon-centered radical (PL), and proceeding with the oxygen addition to peroxyl radical (PL-OO) to yield a phospholipid hydroperoxide (PL-OOH)