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Cellular GSSG accumulation, as opposed to GSH reduction, rendered hepatocytes susceptible to TNF cytotoxicity Increased GSSG/GSG ratios in response to H 2 O 2 exposure can stem from both GSH reduction and GSSG accumulation (data not shown)

As a major cause of tooth loss in adults, periodontitis significantly impacts both oral and systemic health [3]

investigated the potential of a photodynamic immunostimulant consisting of a photosensitizer (dihydroporphyrin e6), an ASCT2 inhibitor (V9302), and a PD1/PDL1 blocker (BMS-1) to inhibit glutamine transport and GSH synthesis by targeting glutamine metabolism