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Animal studies have shown that P140 treatment reduces the clinical and histological severity of colitis in CD-induced mice, suggesting it may serve as a valuable therapeutic target for IBD [104]

A., Yousaf M

Recent evidence suggests another important function of NO is to regulate intracellular trafficking of vesicles and cargo

The etiology of these symptoms is unknown, however several illness-causing mechanisms have been hypothesized, including microbial persistence, host immune dysregulation through inflammatory or secondary autoimmune pathways, or altered neural networks, as in central sensitization