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Although not life-threatening, alopecia areata is most certainly life-altering, and its sudden onset, recurrent episodes, and unpredictable course have a profound psychological impact on the lives of those disrupted by this disease

10.1161/CIRCRESAHA.115.304437 63 ForresterS

Increased ROS levels may result from excitotoxicity, mitochondrial oxidation, misfolded protein aggregation, and neuroinflammation in NDDs [19, 59, 61, 79]