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This action is likely related to SINs ability to enhance IB protein expression, effectively inhibiting NF-B signaling and regulating micro-glial inflammation (4, 95, 96)

While its exact cause remains unknown, factors like genetics, environmental triggers, and abnormalities in blood vessels and immune responses may contribute to the symptoms

The Weapons: Cytokines and Chemical Mediators All cells involved in inflammatory responses communicate with one another via abundant and complex signals that have multiple and sometimes apparently conflicting roles in regulating what is potentially a highly destructive process

Innervation from splanchnic afferent extends throughout the entire gastrointestinal tract [4]