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Familial hypercholesterolemias: prevalence, genetics, diagnosis and screening recommendations from the National Lipid Association Expert Panel on Familial Hypercholesterolemia

doi: 10.1111/j.1365-2672.2012.05434.x 92 BarrettERossRPOtoolePWFitzgeraldGFStantonC

Given that muscle atrophy is associated with reduced serum and urinary creatinine concentrations in patients with FCMD compared to healthy controls 25 , tetranor-PGDM and tetranor-PGEM concentrations normalized to serum creatinine are better indicators of PGD 2 and PGE 2 production in the muscle tissue of patients with FCMD

The central filament stalk is decorated by highly flexible CDs, where the active site entrance loops are free to open and hence increase the accessibility for substrates (Supplementary Fig