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Within this space, it achieves elevated concentrations, surpassing the resilience of most bacterial defense mechanisms, including efflux pumps, porins, and beta-lactamases

doi:10.1016/j.neuron.2012.08.036 Sam C, Bordoni B

3.4.3 Notch signaling pathway After chronic stress triggers an increase in circulating CORT levels, it also activates the Notch signaling pathway, inducing immune suppression and splenocyte apoptosis (233)