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Unraveling mucin domains in cancer and metastasis: When protectors become predators

32%, p 30 kg/m2 is a worldwide epidemic

J Clin Endocrinol Metab 89 : 16131617 Skjaerbaek C et al

Similarly, iridium (III) complexes trigger ferroptosis and autophagy in A549 cells through GSH depletion, MDA/LPO elevation, GPX4/ferritin downregulation, and BECN1-mediated ferritinophagy-all in an HMGB1-dependent manner ( Lung adenocarcinoma (LUAD), the most prevalent NSCLC subtype, often develops resistance to epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) resistance and exhibits low immune checkpoint expression