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The enzyme, ketosteroid isomerase, obtained from several bacterial species has subsequently been extensively investigated by incisive structural and functional studies owing to its extraordinary catalytic efficiency (Yabukarski et al., 2020

In 10, the MR-visible disease was reported to shrink, 164 stabilised, and in 6 worsened, with PSA progressing at a higher-than-average rate in all 6 patients, suggesting no PSA masking effect