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Anastomoses between two defects in the corresponding tissues (i.e., in esophagus and skin (Cesarec et al., 2013), stomach and skin (Skorjanec et al., 2009), duodenum and skin (Skorjanec et al., 2015), colon and skin (Klicek et al., 2008), colon and bladder (Grgic et al., 2016), and rectum and vagina (Baric et al., 2016)) depict the various fistulas (Sikiric et al., 2020a)

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Zinc has been shown to modulate several crucial immune pathways, enhancing chemotaxis in neutrophils [12], promoting cytotoxic activity in NK cells [13], supporting macrophage phagocytic function [14], and preserving responsiveness of T and B cells [15, 16], which are essential components of adaptive immunity