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Patients with active infections, certain autoimmune conditions, active malignancy, or pregnancy are typically not candidates and these are screened at consultation

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Since the cloning of the first OR, those models have been superseded by heterologous expression systems (HEK, CHO, COS-7, Xenopus laevis oocyte) in which OR are easily expressed in large amount but whose cellular characteristics are far from neurons in which OR are endogenously expressed

Preclinical studies and veterinary use have suggested benefit in tendon and muscle repair, with observed anti-inflammatory effects and proangiogenic activity that mirror those of BPC-157