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The entire set of reactions can be summarized as follows: The overall reaction for this process is: Glucose 6-phosphate + 2 NADP + + H 2 O ribulose 5-phosphate + 2 NADPH + 2 H + + CO 2 Non-oxidative phase [edit] Net reaction: 3 ribulose-5-phosphate 1 ribose-5-phosphate + 2 xylulose-5-phosphate 2 fructose-6-phosphate + glyceraldehyde-3-phosphate Regulation [edit] Glucose-6-phosphate dehydrogenase is the rate-controlling enzyme of this pathway

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Figures 1E, F), suggesting that DNA methylation may contribute, at least in part, to the basal repression of MAPKAPK2 in vitiligo melanocytes