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Overall, SHMT plays important roles in various pathological conditions and participates in the occurrence and development of multiple cancers

Notably, NF-B is involved also in hypoxic conditions, and evidence of a crosstalk between NF-B and HIF-1 is growing

In addition, the tricarboxylic acid cycle or electron transfer chain in the mitochondria can promote lipid ROS accumulation and is involved in cysteine-deprivation-induced ferroptosis [18]

Alterations in Antioxidant Defense Systems in Schizophrenia Clinical and preclinical investigations of the actions of antioxidative defense systems in the brain suggest several ways in which ongoing oxidative stress might impact the occurrence and course of schizophrenia