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doi: 10.1007/s00429-006-0109-x 90 HuQXOttestad-HansenSHolmsethSHasselBDanboltNCZhouY

When human lung fibroblasts at low passage number (20) were compared to cells at high passage number (60), a 4 h treatment with resveratrol (100 M) led to an increase in BMAL1 , REV-ERB and SIRT1 mRNA levels in cells with a low passage number while the levels of GDF11 , NRF2 , PER1 , and SIRT6 were decreased