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IF MORE SPACE IS REQUIRED IN FILLING OUT ANY PORTION OF THIS FORM, ATTACH ADDITIONAL SHEETS SECTION - APPOINTMENT Appointed by MAJOR GENERAL JOSEPH M

some drugs and genetic interventions that are highly beneficial/detrimental in one model have either the opposite or no effect in the other

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Although part of this effect may be accounted for by adaptations that take place at synaptic and network levels [4], receptor adaptations are also involved since tolerance is paralleled by receptor desensitization [37, 78, 8184] and down regulation [81, 85]