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Exp Mol Med 49 , e322, (2017)

Besides, sexual dimorphism in GH secretion was observed in rats (66) and humans (67, 68), with large nocturnal GH pulses and low interpeak levels in males, and a higher interpeak and more sustained secretion in females (38)

The ROS generated from aerobic respiration caused a cumulative oxidative damage in macromolecules, including lipids, DNA, and proteins, which subsequently lead to cells death (Scheibye-Knudsen et al., 2015), and affect the healthspan of numerous principal organ systems (Dai et al., 2014)