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PDE5i are widely used to treat ED (178) due to its capability to increase cGMP and/or cAMP levels, leading to activation of PKG/PKA and smooth muscle relaxation in erectile tissues (179181)

Pharmacological inhibition of p-STAT3 markedly reduces both hepatocyte pyroptosis and fibrosis [160]

These findings underline the important role of CYPOR as an electron donor for the reduction of NFT, but do not exclude the involvement of other reductases in NFT reduction