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Notably, applying low-intensity pulsed ultrasound (LIPUS) before AM-MSCs transplantation has been shown to enhance therapeutic efficacy (170)

without it, T cells encountering antigens may fail to activate fully or enter an anergic state

The European journal of neuroscience

The effects of substances of abuse include direct activation of DA neurons, increased DA release, blockade of DA reuptake, and DA neuron de-inhibition (67)